Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B12, and folate in a postmenopausal population.

Plain-language guide to PMID 35149326 (2022): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12).

Key Facts

PMID: 35149326
Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Year: 2022
Study type: Randomized Controlled Trial
Authors: Vázquez-Lorente H et al. (5 authors)
DOI: 10.1016/j.jtemb.2022.126942

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12).

The present study assesses the effect of 8-week Zn supplementation upon circulating concentrations of Hcy, B12, and Fol levels in a population of postmenopausal women.

Who Took Part

The age groups tagged for this paper are adults, middle-aged adults and older adults, women only.

Fifty-one postmenopausal women aged between 44 and 76 years took part in the study.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Nutrient intake was assessed based on the 72-hour recall method.

Zinc was analyzed by flame atomic absorption spectrophotometry.

Clinical-nutritional parameters were determined by enzyme immunoassay techniques.

What Was Measured

The present study assesses the effect of 8-week Zn supplementation upon circulating concentrations of Hcy, B12, and Fol levels in a population of postmenopausal women.

Topics PubMed links to this paper include Dietary Supplements, Folic Acid, Homocysteine, Postmenopause, Vitamin B 12, Vitamins and Zinc.

Author keywords: Folate, Vitamin B(12) and Zinc supplementation.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Cyanocobalamin (Vitamin B12).

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Cyanocobalamin (Vitamin B12) compound page, all human trials.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.