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The effect of infant vitamin B12 supplementation on neurodevelopment: a follow-up of a randomised placebo-controlled trial in Nepal.
Plain-language guide to PMID 35152918 (2023): double-blind randomized controlled trial of Cyanocobalamin (Vitamin B12) in 600 infants.
Key Facts
- PMID
- 35152918
- Journal
- The British journal of nutrition
- Year
- 2023
- Study type
- Randomized Controlled Trial
- Authors
- Ulak M et al. (10 authors)
- DOI
- 10.1017/S0007114522000071
What This Study Did, in Plain Language
What Was Tested
Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.
The primary objective of the current study was to measure the effect of the intervention on the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) full scale intelligence quotient (FSIQ).
Why It Was Studied
The most critical period for brain development is before a child's second birthday.
Standardised tests measuring neurodevelopment are more reliable when administered after this period.
Who Took Part
According to the abstract, 600 infants were involved.
The age groups tagged for this paper are infants and young children.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The infants were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.
Neither the infants nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Cyanocobalamin (Vitamin B12) could be set against what happens without it.
What Was Measured
Standardised tests measuring neurodevelopment are more reliable when administered after this period.
The researchers measured the effect on the Bayley Scales of Infant and Toddler Development 3rd edition at age 30-35 months (n 555).
PubMed files the paper under topics including Vitamin B 12, Nepal, Child Development, Cognition, Dietary Supplements and Vitamins.
Author keywords: Children, Full scale IQ, Neurodevelopment and Vitamin B12 supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 600 infants.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2023 (The British journal of nutrition), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.