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Use of intraoperative parathyroid hormone measurements during parathyroidectomy to predict postoperative parathyroid hormone levels in patients with renal hyperparathyroidism: meta-analysis.
Plain-language guide to PMID 35179187 (2022): meta-analysis of Parathyroid Hormone (PTH 1-84), hyperparathyroidism.
Key Facts
- PMID
- 35179187
- Journal
- BJS open
- Year
- 2022
- Study type
- Meta-Analysis
- Authors
- van Beek DJ et al. (6 authors)
- DOI
- 10.1093/bjsopen/zrab151
What This Paper Covers, in Plain Language
What It Covers
The paper reports a study of Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism, published as a meta-analysis.
Therefore, the literature was systematically reviewed to assess a correlation between ioPTH and early postoperative parathyroid hormone (PTH) levels in patients undergoing PTX for rHPT, separately for those on dialysis and those with a functioning renal transplant.
Fixed-effect and random-effects models were performed to assess the mean ioPTH levels at 10 or 20 min after resection (T10 and T20).
Why It Was Studied
Several studies have reported on the use of intraoperative parathyroid hormone (ioPTH) measurements during parathyroidectomy (PTX) for renal hyperparathyroidism (rHPT), but there is no consensus on whether it is helpful and, if so, what protocol should be used.
Who the Included Studies Covered
Quality assessment was performed using the Quality In Prognosis Studies tool.
Stratified analyses were performed for patients on dialysis and those with a functioning renal transplant.
How the Review Was Done
A systematic literature search was performed in electronic databases.
What Was Measured
Several studies have reported on the use of intraoperative parathyroid hormone (ioPTH) measurements during parathyroidectomy (PTX) for renal hyperparathyroidism (rHPT), but there is no consensus on whether it is helpful and, if so, what protocol should be used.
PubMed files the paper under topics including Hyperparathyroidism, Monitoring, Intraoperative, Parathyroid Hormone, Parathyroidectomy and Renal Dialysis.
What This Means in Plain Language
This is a meta-analysis of Parathyroid Hormone (PTH 1-84) in people with hyperparathyroidism.
Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2022 (BJS open), a journal based in England.
More context: the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.