Effects of Vitamin D supplementation on resolution of fever and cough in children with pulmonary tuberculosis: A randomized double-blind controlled trial in Indonesia.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Studies on vitamin D and its relationship with childhood TB still lack in Indonesia as a country with the second-highest TB incidence globally.

This study evaluated the effect of vitamin D supplementation on resolution of cough and fever in Indonesian children with pulmonary TB.

Who Took Part

The age groups tagged for this paper are children, teenagers and adults.

The researchers conducted a randomized controlled trial of vitamin D supplementation in children with pulmonary TB and vitamin D insufficiency.

How the Study Was Run

The design is described as randomized and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

The secondary outcome in this study was 25-hydroxyvitamin D serum level and nutritional status which was reviewed at the end of the trial.

Intention to treat analyses were applied.

Differences in clinical outcomes between two groups were calculated using Mann-Whitney U test or χ2 test, where appropriate.

What Was Measured

This study evaluated the effect of vitamin D supplementation on resolution of cough and fever in Indonesian children with pulmonary TB.

The subject headings attached to it are Cough, Dietary Supplements, Indonesia, Tuberculosis, Pulmonary and Vitamin D.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (Journal of global health), a journal based in Scotland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.