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Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial.
Plain-language guide to PMID 35253448 (2022): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 164 participants.
Key Facts
- PMID
- 35253448
- Journal
- Journal of the American Heart Association
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Schutten JC et al. (11 authors)
- DOI
- 10.1161/JAHA.121.021783
- Registered trial
- NCT03632590
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Yet, to their knowledge, no head-to-head comparison between various magnesium formulations in terms of effects on arterial stiffness has been performed.
The researchers assessed the effects of magnesium citrate supplementation on arterial stiffness and blood pressure and explored whether other formulations of magnesium have similar effects.
Who Took Part
The abstract describes 164 participants taking part.
PubMed indexes the participants as middle-aged adults and older adults, women only.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
The researchers assessed the effects of magnesium citrate supplementation on arterial stiffness and blood pressure and explored whether other formulations of magnesium have similar effects.
The primary outcome was carotid-to-femoral pulse wave velocity, which is the gold standard method for measuring arterial stiffness.
PubMed files the paper under topics including Blood Pressure, Citric Acid, Dietary Supplements, Magnesium, Magnesium Oxide, Magnesium Sulfate and Organometallic Compounds.
Author keywords: arterial stiffness, intervention study, pulse wave velocity and supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 164 participants.
The publication is from 2022 (Journal of the American Heart Association), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.