Effect of vitamin D monotherapy on indices of sarcopenia in community-dwelling older adults: a systematic review and meta-analysis.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a meta-analysis.

The aim of this systematic review and meta-analysis was to investigate the impact of vitamin D supplementation monotherapy on indices of sarcopenia in community-dwelling older adults.

Who the Included Studies Covered

PubMed indexes the participants as older adults.

Eligible randomized controlled trials (RCTs) compared the effect of vitamin D supplementation (as monotherapy) with placebo on indices of sarcopenia in older (>50 years) adults.

How the Review Was Done

A comprehensive search of the literature was conducted in PubMed, Web of Science, Scopus, and Cochrane Library.

Using the random effects inverse-variance model, the researchers calculated the mean difference (MD) in handgrip strength (HGS), short physical performance battery (SPPB), timed up and go (TUG), and appendicular lean mass (ALM) between groups.

The researchers also calculated the standardized mean difference (SMD) in general muscle strength and general physical performance (composite plot of all muscle strength and physical performance outcomes, respectively) between groups.

What Was Measured

The subject headings attached to it are Dietary Supplements, Independent Living, Sarcopenia, Vitamin D and Vitamins.

The authors tagged it with the keywords Frailty, Handgrip strength, Older adults and Physical performance.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (Journal of cachexia, sarcopenia and muscle), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.