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Effect of monthly vitamin D supplementation on cardiac biomarkers: A post-hoc analysis of a randomized controlled trial.
Plain-language guide to PMID 35272017 (2022): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 779 participants.
Key Facts
- PMID
- 35272017
- Journal
- The Journal of steroid biochemistry and molecular biology
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Wu Z et al. (8 authors)
- DOI
- 10.1016/j.jsbmb.2022.106093
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The effects of vitamin D supplementation on cardiovascular diseases are controversial.
Adjusted relative difference (aRD) of follow-up geometric mean of biomarkers and adjusted relative risk (aRR) of elevated biomarkers between two groups were calculated.
Who Took Part
The abstract describes 779 participants taking part.
By PubMed's age tags, the people studied were older adults.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
A total of 779 participants aged 50-84 y, randomized to vitamin D (n = 395) or placebo (n = 384) groups underwent sampling for measurement of plasma biomarkers at baseline and after one or two years treatment.
PubMed files the paper under topics including Biomarkers, Cardiovascular Diseases, Dietary Supplements, Peptide Fragments, Troponin T, Vitamin D and Vitamins.
The authors tagged it with the keywords Cardiac biomarkers, Older adults, Randomized controlled trial and Vitamin D supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 779 participants.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2022 (The Journal of steroid biochemistry and molecular biology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.