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Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.
Plain-language guide to PMID 35294962 (2022): double-blind randomized controlled trial of Copper (Supplement) in 21,442 adults.
Key Facts
- PMID
- 35294962
- Journal
- The American journal of clinical nutrition
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Sesso HD et al. (13 authors)
- DOI
- 10.1093/ajcn/nqac055
- Registered trial
- NCT02422745
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Copper (Supplement), published as a randomized controlled trial.
Cocoa extract is a source of flavanols that favorably influence vascular risk factors in small and short-term trials, yet effects on clinical cardiovascular events are untested.
Who Took Part
The abstract describes 21,442 adults taking part.
The age groups tagged for this paper are older adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The adults were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.
Neither the adults nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.
The intervention phase was June 2015 through December 2020.
This article reports on the cocoa extract intervention.
What Was Measured
Cocoa extract is a source of flavanols that favorably influence vascular risk factors in small and short-term trials, yet effects on clinical cardiovascular events are untested.
The subject headings attached to it are Cacao, Cardiovascular Diseases, Dietary Supplements, Myocardial Infarction, Neoplasms, Plant Extracts and Polyphenols.
The authors tagged it with the keywords cancer, cocoa extract, flavanols, multivitamin and randomized clinical trial.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) in 21,442 adults.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2022 (The American journal of clinical nutrition), a journal based in United States.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.