← Human Trials & Peer-Reviewed Studies
Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial.
Plain-language guide to PMID 35487792 (2022): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 35487792
- Journal
- Archives of medical research
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Villasis-Keever MA et al. (16 authors)
- DOI
- 10.1016/j.arcmed.2022.04.003
- Registered trial
- NCT04535791
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies.
Who Took Part
Frontline healthcare workers from four hospitals in Mexico City, who tested negative for SARS-CoV-2 infection, were enrolled between July 15 and December 30, 2020.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.
A double-blind, parallel, randomized trial was conducted.
RT-PCR tests were taken at baseline and repeated if COVID-19 manifestations appeared during follow-up.
Serum 25-hydroxyvitamin D3 and antibody tests were measured at baseline and at day 45.
Per-protocol and intention-to-treat analysis were conducted.
What Was Measured
PubMed files the paper under topics including COVID-19, Calcifediol, Cross-Sectional Studies, Dietary Supplements, Health Personnel, SARS-CoV-2 and Vitamin D.
The authors tagged it with the keywords 25-hydroxyvitamin D3 and Healthcare workers.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2022 (Archives of medical research), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.