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The effect of vitamin D supplementation on the outcome of treatment with bevacizumab in diabetic macular edema: a randomized clinical trial.
Plain-language guide to PMID 35543853 (2022): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 83 patients.
Key Facts
- PMID
- 35543853
- Journal
- International ophthalmology
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Fekri S et al. (5 authors)
- DOI
- 10.1007/s10792-022-02333-2
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Concomitant vitamin D deficiency (VDD) is speculated to aggravate diabetic macular edema (DME).
The researchers aimed to determine the effect of hypovitaminosis D correction on the outcome of treatment with intravitreal bevacizumab (IVB) in DME eyes.
Why It Was Studied
Iranian Registry of Clinical Trials (IRCT), IRCT20200407046978N1, registered on April 11, 2020, retrospectively registered ( https://en.irct.ir/trial/46999 ).
Who Took Part
According to the abstract, 83 patients were involved.
In this randomized clinical trial, 83 eyes of 83 patients with DME were recruited and divided into three groups: normal vitamin D levels + IVB administration (Group 1), vitamin D insufficient/deficient + IVB administration (Group 2), and vitamin D insufficient/deficient + IVB administration + oral vitamin D supplementation (Group 3).
How the Study Was Run
In design terms this was a randomized study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Serum vitamin D levels were measured 1 and 6 months after the third IVB administration.
What Was Measured
The subject headings attached to it are Macular Edema, Bevacizumab, Diabetic Retinopathy, Diabetes Mellitus, Type 2, Iran, Angiogenesis Inhibitors and Intravitreal Injections.
Author keywords: Diabetic macular edema and Vitamin D.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 83 patients.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2022 (International ophthalmology), a journal based in Netherlands.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.