Impact of Adequate Day 30 Post-Pediatric Hematopoietic Stem Cell Transplantation Vitamin D Level on Clinical Outcome: An Observational Cohort Study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

This prospective observational study evaluated the impact of adequate vitamin D levels by day +30 after vitamin D supplementation on early post-HSCT outcomes, including acute graft-versus-host disease (aGVHD), immune recovery, infection rates, and overall survival.

Thirty patients with normal vitamin D levels (≥30 ng/mL) were compared with 10 patients with low day +30 vitamin D levels (<30 ng/mL).

Who Took Part

The abstract describes 10 patients taking part.

PubMed indexes the participants as young children, children and teenagers.

Forty children (age 2 to 16 years) undergoing hematopoietic stem cell transplantation (HSCT) were given vitamin D supplementation, were followed prospectively from day +30 post-transplantation, and had day +30 vitamin D levels measured.

What Was Measured

This prospective observational study evaluated the impact of adequate vitamin D levels by day +30 after vitamin D supplementation on early post-HSCT outcomes, including acute graft-versus-host disease (aGVHD), immune recovery, infection rates, and overall survival.

Thirty patients with normal vitamin D levels (≥30 ng/mL) were compared with 10 patients with low day +30 vitamin D levels (<30 ng/mL).

Topics PubMed links to this paper include Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Vitamin D, Vitamin D Deficiency and Vitamins.

The authors tagged it with the keywords Allogenic hematopoietic stem cell transplantation and Pediatrics.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 10 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2022 (Transplantation and cellular therapy), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.