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A randomized clinical trial to assess the effect of zinc and vitamin D supplementation in addition to hypertonic saline on treatment of acute bronchiolitis.
Plain-language guide to PMID 35692038 (2022): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 94 infants.
Key Facts
- PMID
- 35692038
- Journal
- BMC infectious diseases
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Khoshnevisasl P et al. (4 authors)
- DOI
- 10.1186/s12879-022-07492-2
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
This study was conducted to assess the effect of Zinc and vitamin D on treatment of infants with bronchiolitis.
Why It Was Studied
Bronchiolitis, the most common cause of hospitalization in infancy has not yet a definitive treatment.
Who Took Part
The study group was 94 infants.
By PubMed's age tags, the people studied were infants and children.
How the Study Was Run
The design is described as randomized and double-blind.
The infants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
In this double blind, randomized clinical trial, 94 infants aged 2 to 23 months, admitted in Mousavi Hospital in Zanjan, Iran, with the diagnosis of acute bronchiolitis were randomly assigned into 3 groups.
The control group was only treated with hypertonic saline.
Wheezing, duration of hospital stay, cough, cyanosis, respiratory distress and the respiratory rate in the first, third and seventh day of hospitalization were evaluated.
What Was Measured
PubMed files the paper under topics including Bronchiolitis, Bronchodilator Agents, Cyanosis, Dietary Supplements, Nebulizers and Vaporizers, Respiratory Sounds and Saline Solution, Hypertonic.
The authors tagged it with the keywords Infant, Vit D and Zinc.
What This Means in Plain Language
The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 94 infants.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2022 (BMC infectious diseases), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.