Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review.

What It Covers

This review looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone).

To determine most common clinical features and diagnostic challenges in ectopic acromegaly.

Why It Was Studied

Ectopic acromegaly is a rare condition caused most frequently by growth hormone releasing hormone (GHRH) secretion from neuroendocrine tumors.

The diagnosis is often difficult to establish as its main symptoms do not differ from those of acromegaly of pituitary origin.

Who the Included Studies Covered

In this article, 127 cases of ectopic acromegaly described after GHRH isolation in 1982 are comprehensively reviewed, along with a summary of current state of knowledge on its clinical features, diagnostic methods, and treatment modalities.

How the Review Was Done

A search for ectopic acromegaly cases available in literature was performed using PubMed, Cochrane, and MEDline database.

The most important data were compiled and compared in the tables.

What Was Measured

PubMed files the paper under topics including Acromegaly, Diagnosis, Differential, Growth Hormone-Releasing Hormone, Neuroendocrine Tumors and Prognosis.

Author keywords: GHRH, ectopic and pituitary hyperplasia.

What This Means in Plain Language

This is a review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone).

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (Frontiers in endocrinology), a journal based in Switzerland.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the GHRH (Growth Hormone-Releasing Hormone) compound page, all human trials.