Parathyroid hormone changes in infants investigated for inflicted injury; an observational retrospective single centre cohort study

Plain-language guide to PMID 35803027 (2022): observational study of Parathyroid Hormone (PTH 1-84).

Key Facts

PMID: 35803027
Journal: Child abuse & neglect
Year: 2022
Study type: Observational Study
Authors: Lewis L et al. (11 authors)
DOI: 10.1016/j.chiabu.2022.105775

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Parathyroid Hormone (PTH 1-84), published as an observational study.

Biochemical and haematological testing is recommended in the United Kingdom when inflicted injury is suspected.

The researchers examined the associations of test results with radiologically-confirmed fracture(s), and between test results, in a large retrospective observational cohort.

Who Took Part

The age groups tagged for this paper are young children and children, men only.

Biochemical parameters: corrected calcium (cCa); phosphate (P); alkaline phosphatase (ALP); parathyroid hormone (PTH); 25-hydroxyvitamin D (25D); and haematological parameters: haemoglobin (Hb); mean corpuscular haemoglobin (MCH); mean corpuscular haemoglobin content (MCHC); mean corpuscular volume (MCV); platelet count were collated together with the results of the radiological assessments.

How the Study Was Run

Infants up to age two years presenting with suspected inflicted injury, without clinically or radiologically apparent bone disease, and where a skeletal survey was undertaken during the period 1st August 2013 to 31st December 2020, were included.

What Was Measured

Biochemical and haematological testing is recommended in the United Kingdom when inflicted injury is suspected.

The researchers examined the associations of test results with radiologically-confirmed fracture(s), and between test results, in a large retrospective observational cohort.

PubMed files the paper under topics including Alkaline Phosphatase, Bone and Bones, Cohort Studies, Fractures, Bone and Parathyroid Hormone.

Author keywords: Infant, Intracranial injury, Suspected inflicted injury and Vitamin D.

What This Means in Plain Language

This is an observational study of Parathyroid Hormone (PTH 1-84).

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (Child abuse & neglect), a journal based in England.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.

Our Notes on the Compound

Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Parathyroid Hormone (PTH 1-84) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.