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Pharmacokinetics of Esomeprazole Magnesium After Single Oral Doses in Healthy Subjects: Bioequivalence Study and Food Effects.
Plain-language guide to PMID 35822412 (2022): open-label randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 33 subjects.
Key Facts
- PMID
- 35822412
- Journal
- Clinical pharmacology in drug development
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Zhong XF et al. (10 authors)
- DOI
- 10.1002/cpdd.1139
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Liquid chromatography-tandem mass spectrometry and WinNonlin software were used to assess the bioequivalence of esomeprazole peak plasma concentration (Cmax ) and area under the concentration-time curve (AUC).
Why It Was Studied
The subjects were administered the test or reference products in a 1:1 ratio at random throughout each period.
Then, in the next session, they received the alternate products.
Who Took Part
The abstract describes 33 subjects taking part.
By PubMed's age tags, the people studied were adults.
How the Study Was Run
The researchers set it up as a randomized, open-label and crossover study.
The subjects were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Nothing was hidden in this open-label Vitamin D, K2, Magnesium and Zinc study: the subjects and staff both knew the treatment.
Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.
What Was Measured
The subjects were administered the test or reference products in a 1:1 ratio at random throughout each period.
PubMed files the paper under topics including Therapeutic Equivalency, Esomeprazole, Healthy Volunteers and Area Under Curve.
The authors tagged it with the keywords bioequivalent, food effects and safety assessment.
What This Means in Plain Language
The paper is a randomized, open-label and crossover study of Vitamin D, K2, Magnesium and Zinc in 33 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2022 (Clinical pharmacology in drug development), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.