Role of Multiple Vitamin D-Related Polymorphisms in Multiple Sclerosis Severity: Preliminary Findings.

What Was Tested

This observational study looks at Vitamin D, K2, Magnesium and Zinc in the context of multiple sclerosis.

The aim of this observational study was to evaluate the potential association among vitamin D status, MS severity, and vitamin D-related SNPs, alone or in combination.

Why It Was Studied

Multiple Sclerosis (MS) is a multifactorial disease whose pathogenesis is the result of interaction among genetic, epigenetic, and environmental factors.

Among these, a role for vitamin D hypovitaminosis has emerged in recent decades.

Who Took Part

According to the abstract, 100 patients were involved.

In a cohort of 100 MS patients, the researchers genotyped 18 SNPs in the following genes: NAD synthetase 1, CYP2R1, vitamin D binding protein, vitamin D receptor, Retinoid X Receptor-α, KLOTHO, CYP24A1, and CYP27A1.

How the Study Was Run

Serum 25(OH)D3 levels were measured by high-performance liquid chromatography.

Genotyping was performed by real-time polymerase chain reaction or PCR-RFLP.

What Was Measured

Vitamin D levels are influenced by both environmental and genetic factors.

However, few studies assessed the association of such SNPs with the severity of the disease.

Topics PubMed links to this paper include Cholestanetriol 26-Monooxygenase, Cytochrome P450 Family 2, Multiple Sclerosis, Vitamin D, Vitamin D3 24-Hydroxylase and Vitamins.

Author keywords: MS, SNP, genetic, prognosis and severity.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 100 patients in people with multiple sclerosis.

Results are reported in around 2 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2022 (Genes), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Multiple sclerosis research.