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[Effect of somatostatin on postoperative gastrointestinal function and stress level in children with acute abdomen: a prospective randomized controlled study]
Plain-language guide to PMID 35894198 (2022): randomized controlled trial study of Somatostatin in 102 children.
Key Facts
- PMID
- 35894198
- Journal
- Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Qi BX et al. (7 authors)
- DOI
- 10.7499/j.issn.1008-8830.2203098
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Somatostatin, published as a randomized controlled trial.
To study the effect of somatostatin on postoperative gastrointestinal function and stress level in children with acute abdomen.
Who Took Part
The study group was 102 children.
By PubMed's age tags, the people studied were children.
A total of 102 children with acute abdomen who underwent surgery in Xuzhou Children's Hospital from August 2019 to June 2021 were enrolled as subjects and were randomly divided into an observation group and a control group, with 51 children in each group.
The children in the control group were given conventional treatment such as hemostasis and anti-infective therapy after surgery, and those in the observation group were given somatostatin in addition to conventional treatment.
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got Somatostatin and who got the comparison, which limits bias.
Peripheral blood samples were collected from both groups before surgery and on days 1 and 5 after surgery.
The two groups were compared in terms of the serum levels of endothelin-1 (ET-1), adrenocorticotropic hormone (ACTH), cortisol, gastrin, and motilin, postoperative recovery, and the incidence rate of complications.
What Was Measured
PubMed files the paper under topics including Abdomen, Abdomen, Acute, Adrenocorticotropic Hormone, Gastrins, Hydrocortisone, Motilin and Postoperative Complications.
The authors tagged it with the keywords Abdominal surgery, Acute abdomen, Child, Gastrointestinal function, Somatostatin and Stress response.
What This Means in Plain Language
The paper is a randomized study of Somatostatin in 102 children.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2022 (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics), a journal based in China.
More context: the Somatostatin compound page, all human trials.
Our Notes on the Compound
Somatostatin: A 14-amino-acid hormone that switches off the release of several other hormones, including growth hormone and insulin.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.