The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.

Plain-language guide to PMID 35918728 (2022): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 64 women, acne.

Key Facts

PMID: 35918728
Journal: Reproductive biology and endocrinology : RB&E
Year: 2022
Study type: Randomized Controlled Trial
Authors: Jaripur M et al. (6 authors)
DOI: 10.1186/s12958-022-00982-7

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc in the context of acne.

To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne.

Why It Was Studied

Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS).

This randomized clinical trial was registered at IRCT.ir on 2020-10-18 (Registration Code: IRCT20130903014551N9 ).

Who Took Part

The study group was 64 women.

PubMed tags the participants as women only.

How the Study Was Run

The researchers set it up as a randomized, placebo-controlled and parallel-group study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.

AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively.

This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9).

What Was Measured

Topics PubMed links to this paper include Acne Vulgaris, Alopecia, Biomarkers, Dietary Supplements, Magnesium, Polycystic Ovary Syndrome and Quality of Life.

Author keywords: Abnormal uterine bleeding.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 64 women in people with acne.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2022 (Reproductive biology and endocrinology : RB&E), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Acne research.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.