Alterations of liver enzymes and lipid profile in response to exhaustive eccentric exercise: vitamin D supplementation trial in overweight females with non-alcoholic fatty liver disease.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of fatty liver & elevated liver enzymes in this randomized controlled trial publication.

This study aimed to investigate the effect of short-term supplementation of Vit D on the liver enzymes and lipid profile alterations following EEE in overweight women with NAFLD.

Why It Was Studied

However, there is limited evidence on the effect of Vit D supplementation on the EEE-induced alterations.

The trial was in the Iranian Clinical Trial Registration Center under the (IRCT20201130049538N1) on 05/07/2021.

Who Took Part

The abstract describes 22 women taking part.

PubMed tags the participants as women only.

In this clinical trial, 22 overweight women with NAFLD were randomly divided into experimental and control (n = 11 in each).

Two treadmill EEE sessions were performed before and after the six-week Vit D supplementation.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Blood was taken from the antecubital vein to measure the liver enzymes, lipid profile, and Vit D at four stages: Pre 1(before the first EEE session), Post 1(after the first EEE session), Pre 2 (before the second EEE session), and Post 2 (after the second EEE session).

What Was Measured

Topics PubMed links to this paper include Dietary Supplements, Iran, Lipids, Non-alcoholic Fatty Liver Disease, Overweight, Vitamin D and Vitamins.

The authors tagged it with the keywords Exercise, Lipid profile, Liver enzymes and NAFLD.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 22 women in people with fatty liver & elevated liver enzymes.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (BMC gastroenterology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Fatty liver & elevated liver enzymes research.