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Influence of Maternal Body Fat on Levels of Insulin, Insulin-Like Growth Factor-1, and Obestatin

Plain-language guide to PMID 35950305 (2022): observational study of IGF-1 LR3 and Ghrelin in 58 participants.

Key Facts

PMID
35950305
Journal
Journal of human lactation : official journal of International Lactation Consultant Association
Year
2022
Study type
Observational Study
Authors
Badillo-Suárez PA et al. (7 authors)
DOI
10.1177/08903344221112946

What This Study Did, in Plain Language

What Was Tested

This observational study looks at IGF-1 LR3 and Ghrelin.

To determine (1) the influence of body fat on levels of insulin, IGF-1, and obestatin in human milk and serum/plasma during the postpartum period; (2) the changes in the levels of these hormones in human milk and serum/plasma postpartum; and (3) the presence of IGF-1 mRNA in human milk.

Student's t test and repeated-measures analysis of variance were used to evaluate the differences between groups.

Why It Was Studied

Insulin, insulin-like Growth Factor-1 (IGF-1), and obestatin in human milk originate from the circulation.

There is also limited knowledge about the influence of body fat on the levels of these hormones in human milk.

Who Took Part

The study group was 58 participants.

PubMed tags the participants as women only.

How the Study Was Run

Pearson's test was used to analyze the associations.

What Was Measured

There is also limited knowledge about the influence of body fat on the levels of these hormones in human milk.

PubMed files the paper under topics including Insulin-Like Growth Factor I, Insulin, Ghrelin, Breast Feeding, Milk, Human, Adipose Tissue and RNA, Messenger.

Author keywords: breastfeeding, evidence-based management, experiential learning, in-class exercises, management education and organizational behavior.

What This Means in Plain Language

This is an observational study of IGF-1 LR3 and Ghrelin in 58 participants.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (Journal of human lactation : official journal of International Lactation Consultant Association), a journal based in United States.

More context: the IGF-1 LR3 compound page and the Ghrelin compound page, all human trials.

Our Notes on the Compounds

IGF-1 LR3: A modified IGF-1 analog that escapes binding proteins, so it stays active ≥24 h.

Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.