Prospective Observational Study of N-terminal Pro-Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy

What Was Tested

Researchers studied BNP (Nesiritide) in this observational study publication.

N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of ventricular dysfunction, varies by body mass index (BMI) outside of pregnancy.

This study aimed to determine whether obesity affects NT-proBNP levels in pregnancy.

Why It Was Studied

· NT-proBNP levels are lower in obese than nonobese patients during pregnancy.. · Levels remain elevated in obese, but not nonobese, patients up to 4 to 6 weeks' postpartum.. · A lower threshold for concern regarding NT-proBNP levels may be needed in obese pregnant people..

Who Took Part

PubMed tags the participants as women only.

This was a prospective observational study of healthy pregnant people in the third trimester (3TM) and postpartum (PP).

How the Study Was Run

NT-proBNP was measured at 28 weeks (3TM), predelivery (PD), 1 to 2 days PP (immediate postpartum [IPP]), and 4 to 6 weeks PP (delayed postpartum [DPP]).

LogNT-proBNP levels were analyzed using linear mixed effects models, including BMI < or ≥30, time, and time-by-BMI interactions.

What Was Measured

· NT-proBNP levels are lower in obese than nonobese patients during pregnancy.. · Levels remain elevated in obese, but not nonobese, patients up to 4 to 6 weeks' postpartum.. · A lower threshold for concern regarding NT-proBNP levels may be needed in obese pregnant people..

PubMed files the paper under topics including Obesity, Natriuretic Peptide, Brain, Peptide Fragments, Comorbidity and Biomarkers.

What This Means in Plain Language

This is a observational study of BNP (Nesiritide).

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2023 (American journal of perinatology), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.