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Effect of Vitamin D Supplementation on Overactive Bladder and Urinary Incontinence Symptoms in Older Men: Ancillary Findings From a Randomized Trial.

Plain-language guide to PMID 36067369 (2023): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID
36067369
Journal
The Journal of urology
Year
2023
Study type
Randomized Controlled Trial
Authors
Markland AD et al. (11 authors)
DOI
10.1097/JU.0000000000002942
Registered trial
CT01169259

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Who Took Part

The age groups tagged for this paper are older adults.

Ancillary study of men aged ≥55 years in VITAL (VITamin D and OmegA-3 TriaL).

Randomized treatments included: vitamin D3 (cholecalciferol), marine omega-3 fatty acids, or matching placebo.

How the Study Was Run

The design is described as randomized and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Structured urinary incontinence questions measured the prevalence of overactive bladder at year 5 and urinary incontinence at years 2 and 5, along with incidence and progression of urinary incontinence from years 2 to 5.

Prespecified subgroup analyses examined men with low baseline serum 25-hydroxyvitamin D (<20 ng/mL).

What Was Measured

PubMed files the paper under topics including Urinary Bladder, Overactive, Urinary Incontinence and Vitamin D.

The authors tagged it with the keywords epidemiology, lower urinary tract symptoms and men.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2023 (The Journal of urology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.