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Vaginal misoprostol versus combined intracervical foley's catheter and oxytocin infusion for second trimester pregnancy termination in women with previous caesarean sections: a randomised control trial
Plain-language guide to PMID 36149628 (2022): randomized controlled trial study of Oxytocin in 158 women.
Key Facts
- PMID
- 36149628
- Journal
- Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Elasy AN et al. (4 authors)
- DOI
- 10.1080/01443615.2022.2118572
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Oxytocin.
The aim of this study was to achieve vaginal expulsion in an expeditious manner with less maternal complications.
Why It Was Studied
Howevere, there is no global agreement regarding the ideal method for induction of the second trimester abortion in a scarred uterus.
A total of 158 women having, a history of previous caesarean section undergoing second trimester pregnancy termination, were randomly allocated into group (1) vaginal misoprostol group (n = 79) or group (2) combined intracervical foley's catheter plus intravenous oxytocin infusion group (n = 79).
Who Took Part
The abstract describes 158 women taking part.
PubMed tags the participants as women only.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got Oxytocin and who got the comparison, which limits bias.
What Was Measured
The primary endpoint was complete fetal expulsion.
Meanwhile, secondary outcomes were the rates of maternal complications, in terms of the need for surgical evacuation of retained product of conception (ERPOC), severe haemorrhage, uterine rupture, blood transfusion, cervical laceration, diarrhoea, vomiting and fever.
Topics PubMed links to this paper include Misoprostol, Oxytocin, Oxytocics, Pregnancy Trimester, Second, Cesarean Section, Labor, Induced and Fetal Diseases.
Author keywords: Second trimester, caesarean delivery, intracervical catheter and pregnancy termination.
What This Means in Plain Language
The paper is a randomized study of Oxytocin in 158 women.
The publication is from 2022 (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology), a journal based in England.
More context: the Oxytocin compound page, all human trials.
Our Notes on the Compound
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.