[Vitamin D and polymorphisms of VDR and GC genes in the severity and mortality from COVID-19. A systematic review].

What It Covers

Researchers studied Vitamin D, K2, Magnesium and Zinc in this systematic review publication.

The objective of this review is to assess whether some VDR and GC SNPs are risk factors for the most severe forms of COVID-19 disease and whether they condition the response to vitamin D supplementation.

Why It Was Studied

This vitamin exerts multiple functions that depend on the presence and levels of different proteins, such as the vitamin D receptor (VDR) and the vitamin D binding protein (DBP), and the existence of single nucleotide polymorphisms (SNPs) of the genes that encode these proteins.

A search was performed in PubMed, Google Scholar and Scielo, finding that genotypes in patients affected by COVID-19, were rarely performed, although some studies find a relationship between different alleles and the severity of the disease.

What Was Measured

This vitamin exerts multiple functions that depend on the presence and levels of different proteins, such as the vitamin D receptor (VDR) and the vitamin D binding protein (DBP), and the existence of single nucleotide polymorphisms (SNPs) of the genes that encode these proteins.

Well-designed studies are needed to elucidate whether plasma vitamin D levels play a role of casuality or causality.

PubMed files the paper under topics including COVID-19, Genotype, Polymorphism, Single Nucleotide, Receptors, Calcitriol, SARS-CoV-2, Vitamin D and Vitamin D Deficiency.

Author keywords: Vitamina D. COVID-19. Genes VDR y GC. Polimorfismos. Mortalidad. Severidad.

What This Means in Plain Language

This is a systematic review of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2022 (Nutricion hospitalaria), a journal based in Spain.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.