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Vitamin D supplementation and exercise for improving physical function, body composition and metabolic health in overweight or obese older adults with vitamin D deficiency: a pilot randomized, double-blind, placebo-controlled trial.

Plain-language guide to PMID 36333495 (2023): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 24, participants.

Key Facts

PMID
36333495
Journal
European journal of nutrition
Year
2023
Study type
Randomized Controlled Trial
Authors
Mesinovic J et al. (10 authors)
DOI
10.1007/s00394-022-03038-z

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

According to the abstract, 24, participants were involved.

The age groups tagged for this paper are middle-aged adults and older adults.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and pilot study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

Mean changes in physical function (primary outcome: gait speed), body composition and biochemical parameters at weeks 12 and 24 were compared between groups.

What Was Measured

PubMed files the paper under topics including Overweight, Pilot Projects, Dietary Supplements, Obesity, Vitamin D, Vitamin D Deficiency and Vitamins.

The authors tagged it with the keywords Body composition, Exercise, Metabolic health and Physical function.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 24, participants.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.