The effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women: a systematic review and meta-analysis of clinical trials.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a meta-analysis.

The aim of this systematic review was to evaluate the effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women according to the PRISMA guidance.

Why It Was Studied

Vitamin D deficiency, a common problem among pregnant women, is linked with maternal inflammation, oxidative stress and consequent adverse pregnancy outcomes.

Registration code in PROSPERO website: CRD42020202600.

Who the Included Studies Covered

PubMed tags the participants as women only.

Clinical trials that assessed 25-Hydroxyvitamin D (25(OH)D), inflammatory markers (including high sensitivity C-reactive protein (hs-CRP) and certain cytokines) and oxidative stress markers (including malondialdehyde (MDA), total antioxidant capacity (TAC) and glutathione (GSH)) in pregnant women, were included in this review.

After removing duplicates and irrelevant articles, 17 eligible RCTs included for more evaluation.

How the Review Was Done

Four databases including PubMed/MEDLINE, Scopus, Web of Science and Cochrane were used for searching papers published until 25th July 2022.

The primary search of three databases displayed 21571 records.

Random effect model and Der Simonian-Laird method were used to pool the data of studies.

Risk of bias assessed according to version 2 of the Cochrane risk-of-bias tool for randomized trials.

What Was Measured

Vitamin D deficiency, a common problem among pregnant women, is linked with maternal inflammation, oxidative stress and consequent adverse pregnancy outcomes.

The subject headings attached to it are C-Reactive Protein, Dietary Supplements, Pregnant People, Oxidative Stress, Biomarkers, Vitamin D and Antioxidants.

The authors tagged it with the keywords Inflammation, Meta-analysis and Pregnancy.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (BMC pregnancy and childbirth), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.