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The Effect of a Single High Dose of Vitamin D on Serum Levels of Its Metabolites in the Elderly.
Plain-language guide to PMID 36336861 (2022): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 58 patients.
Key Facts
- PMID
- 36336861
- Journal
- Frontiers in bioscience (Landmark edition)
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Leszczyńska D et al. (8 authors)
- DOI
- 10.31083/j.fbl2710289
- Registered trial
- NCT05591170
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
However, the usage of liquid chromatography with tandem mass spectrometry (LC-MS/MS) technique allows to reliably assess a panel of vitamin D metabolites in serum or plasma, which may help to investigate the metabolic paths of vitamin D, especially in populations at risk of deficiency.
Why It Was Studied
Vitamin D is a dietary micronutrient responsible for calcium and phosphorus metabolism and multiple extraskeletal actions.
The assessment of vitamin D status is commonly based on measurement of 25(OH)D total concentration in serum.
Who Took Part
The abstract describes 58 patients taking part.
By PubMed's age tags, the people studied were middle-aged adults, older adults and people over 80, both men and women.
A randomized, two-arms, open study was conducted on 58 patients (28 female and 30 male; aged from 61 to 96 years old).
How the Study Was Run
In design terms this was a randomized study.
The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
What Was Measured
The assessment of vitamin D status is commonly based on measurement of 25(OH)D total concentration in serum.
The subject headings attached to it are Calcium, Cholecalciferol, Chromatography, Liquid, Tandem Mass Spectrometry and Vitamin D.
The authors tagged it with the keywords 25(OH)D2, 25(OH)D3, 3-epi-25(OH)D3, elderly, metabolites and supplementation.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 58 patients.
The abstract goes on to report its results in about 10 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2022 (Frontiers in bioscience (Landmark edition)), a journal based in Singapore.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.