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Application of methylene blue combined with ropivacaine intercostal nerve block in postoperative analgesia of autologous costal cartilage augmentation rhinoplasty
Plain-language guide to PMID 36414741 (2022): randomized controlled trial study of Methylene blue (non-peptide stack partner) in 100 patients.
Key Facts
- PMID
- 36414741
- Journal
- Die Anaesthesiologie
- Year
- 2022
- Study type
- Randomized Controlled Trial
- Authors
- Guoyu J et al. (3 authors)
- DOI
- 10.1007/s00101-022-01222-8
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Methylene blue (non-peptide stack partner).
To observe the effect of methylene blue combined with ropivacaine intercostal nerve block on postoperative analgesia after autologous costal cartilage augmentation rhinoplasty.
Who Took Part
The abstract describes 100 patients taking part.
PubMed tags the participants as women only.
In this study 100 female patients who underwent autologous costal cartilage comprehensive augmentation rhinoplasty in Chongqing Huamei Plastic Surgery Hospital from April to November 2021 were randomly divided into an experimental group and a control group, with 50 cases in each group.
In the experimental group methylene blue was combined with ropivacaine intercostal nerve block as patient controlled intravenous analgesia (PCIA), and the control group was ropivacaine intercostal nerve block combined with PCIA.
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got Methylene blue (non-peptide stack partner) and who got the comparison, which limits bias.
The visual analogue scale (VAS) scores of resting and coughing at 6 h (T1), 24 h (T2), 48 h (T3), 72 h (T4) after surgery were recorded and evaluated.
At the same time, the number and times of oral analgesics were recorded as well as nausea, vomiting, burning pain and paresthesia.
What Was Measured
The subject headings attached to it are Ropivacaine, Methylene Blue, Costal Cartilage, Intercostal Nerves, Nerve Block, Rhinoplasty and Postoperative Pain.
The authors tagged it with the keywords Autologous costal cartilage comprehensive augmentation rhinoplasty, Intercostal nerve block and Postoperative analgesia.
What This Means in Plain Language
The paper is a randomized study of Methylene blue (non-peptide stack partner) in 100 patients.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2022 (Die Anaesthesiologie), a journal based in Germany.
More context: the Methylene blue (non-peptide stack partner) compound page, all human trials.
Our Notes on the Compound
Methylene blue (non-peptide stack partner): Described as an electron cycler, not just a dye.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.