Granulocyte colony stimulating factor versus human chorionic gonadotropin for recurrent implantation failure in intra cytoplasmic sperm injection: a randomized clinical trial.

Plain-language guide to PMID 36447142 (2022): single-blind randomized controlled trial of hCG (human chorionic gonadotropin) in 100 women.

Key Facts

PMID: 36447142
Journal: BMC pregnancy and childbirth
Year: 2022
Study type: Randomized Controlled Trial
Authors: Bakry MS et al. (13 authors)
DOI: 10.1186/s12884-022-05098-9

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of hCG (human chorionic gonadotropin), published as a randomized controlled trial.

Repeated implantation failure (RIF) is defined as the case whereby the transferred embryos fail to implant after several attempts of In vitro fertilization (IVF) which causes a profound impact on the quality of life and financial burden.

The study was registered on Pan African Clinical Trials Registry with the following number: PACTR202010482774275 and was approved on 2nd October 2020.

Who Took Part

The study group was 100 women.

The age groups tagged for this paper are young adults and adults, both men and women.

The study included 100 women aged 20-43 years old undergoing ICSI cycles, with a history of RIF.

How the Study Was Run

In design terms this was a randomized and single-blind study.

The women were allocated by chance, so the hCG (human chorionic gonadotropin) group and the comparison group should start out alike.

Only one side, usually the women, was kept unaware of whether hCG (human chorionic gonadotropin) was given.

This randomized, single-blinded study was conducted et al.-Azhar University Hospitals, Cairo, Egypt, between 10th October 2020 and 20th December 2020.

What Was Measured

Topics PubMed links to this paper include Abortion, Spontaneous, Chorionic Gonadotropin, Granulocyte Colony-Stimulating Factor, Quality of Life, Semen, Sperm Injections, Intracytoplasmic and Spermatozoa.

The authors tagged it with the keywords G-CSF, HCG, ICSI, IVF and RIF.

What This Means in Plain Language

The paper is a randomized and single-blind study of hCG (human chorionic gonadotropin) in 100 women.

Its findings take up roughly 2 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (BMC pregnancy and childbirth), a journal based in England.

More context: the hCG (human chorionic gonadotropin) compound page, all human trials.

Our Notes on the Compound

hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.

hCG (human chorionic gonadotropin) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.