Effects of a 2-Year Early Childhood Vitamin D3 Intervention on Tooth Enamel and Oral Health at Age 6-7 Years.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Who Took Part

The study group was 975 infants.

By PubMed's age tags, the people studied were infants, young children and children, both men and women.

For the present follow-up study at age 6-7 years, a sample of 123 children underwent oral examination by investigators blinded to the intervention group.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the infants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Tooth enamel defect and caries findings, oral rinse active matrix metalloproteinase-8 levels, and tooth eruption were recorded.

The intervention groups were compared with χ2 and Mann-Whitney U tests.

Associations of the oral health outcomes were evaluated with correlation analysis and logistic regression.

What Was Measured

Topics PubMed links to this paper include Oral Health, Vitamin D, Cholecalciferol, Vitamins, Dental Enamel, Dietary Supplements and Vitamin A.

The authors tagged it with the keywords Matrix metalloproteinase and Molar-incisor hypomineralization.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 975 infants.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2023 (Hormone research in paediatrics), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.