Effectiveness of Vitamin D along with Splint therapy in the Vit D deficient patients with Temporomandibular disorder-A Randomized, double-blind, placebo-controlled clinical trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The purpose of this study is to comparatively evaluate the Vitamin D supplementation and stabilization splint therapy in patients exhibiting temporomandibular disorders (TMD).

Why It Was Studied

For intergroup comparison, Mann-Whitney U-test and Pearson Chi-square tests were done.

For Intragroup comparison, Wilcoxon signed rank test was used for comparison.

Who Took Part

The study design was double-blinded, parallel-group, randomized and placebo-controlled trial conducted in patients with low Vitamin D and TMDs, which were allocated to two groups, Study group S + D (Stabilization splint with Vitamin D supplementation) and Control Group S (Stabilization Splint with placebo drug).

Thirty-six participants of 18-45 years of age gap with Vitamin D deficiency and TMD were included in the study.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and parallel-group.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Groups ran in parallel: each of the participants stayed in one arm throughout.

Preoperative values of Vitamin D levels in ng/ml, comfort mouth opening (CMO) in mm, maximum mouth opening (MMO) in mm, temporomandibular joint (TMJ) tenderness (grading 0-3), Visual analog scale score (VAS Score 0-10 cm), and total energy (TE) integral values of both left and right TMJ's in Hertz (Hz) were recorded using joint vibration analysis All the values of CMO, MMO, TMJ Tenderness and VAS were recorded at each follow-up at 1st week, 1st month, 2nd month, and 3rd month, respectively.

Postoperative Vitamin D levels and TE of both TMJs were recorded at end of 3 months.

What Was Measured

For intergroup comparison, Mann-Whitney U-test and Pearson Chi-square tests were done.

For Intragroup comparison, Wilcoxon signed rank test was used for comparison.

Topics PubMed links to this paper include Occlusal Splints, Vitamin D, Temporomandibular Joint Disorders, Splints and Arthralgia.

The authors tagged it with the keywords 1, 25 dihydroxy 20 epi Vitamin D3, joint vibration and temporomandibular disorders.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2022 (Journal of Indian Prosthodontic Society), a journal based in India.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.