Serum oxytocin and corticotropin-releasing hormone levels in the third trimester of pregnancy for predicting postpartum depression in Thai women

What Was Tested

The paper reports a study of Oxytocin and ACTH (Corticotropin), published as an observational study.

This prospective observational study aimed to determine whether serum oxytocin (OT) or corticotrophin-releasing hormone (CRH) levels in the third trimester of pregnancy (or late pregnancy) could prospectively predict postpartum depression (PPD) at six weeks after childbirth.

Multivariable binary logistic regression analysis was performed to determine the predictors of PPD.

Who Took Part

PubMed tags the participants as women only.

The researchers measured late pregnancy OT and CRH levels in Thai women, assessed depression using the Edinburgh Postnatal Depression Scale (EPDS) and Patient Health Questionnaire-9 (PHQ-9), and collected mothers, labor, and newborn data.

How the Study Was Run

At six weeks postpartum, an EPDS score ≥ 11 or PHQ-9 score ≥ 10 was defined as the presence of PPD.

What Was Measured

Topics PubMed links to this paper include Corticotropin-Releasing Hormone, Depression, Postpartum, Oxytocin, Postpartum Period, Pregnancy Trimester, Third, Risk Factors and Southeast Asian People.

The authors tagged it with the keywords Corticotrophin-releasing hormone, Edinburgh Postnatal Depression Scale, Patient Health Questionnaire-9, Postpartum depression and Predictors.

What This Means in Plain Language

This is an observational study of Oxytocin and ACTH (Corticotropin).

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2023 (Asian journal of psychiatry), a journal based in Netherlands.

More context: the Oxytocin compound page and the ACTH (Corticotropin) compound page, all human trials.