Effects of magnesium, phosphate, or zinc supplementation in intensive care unit patients-A systematic review and meta-analysis.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc.

The researchers aimed to assess the desirable and undesirable effects of supplementation with magnesium, phosphate, or zinc in adult ICU patients.

Why It Was Studied

Low-serum levels of magnesium, phosphate, and zinc are observed in many intensive care unit (ICU) patients, but clinical equipoise exists regarding supplementation strategies.

Who the Included Studies Covered

The age groups tagged for this paper are adults.

The researchers conducted a systematic review with meta-analysis of randomised clinical trials assessing the effects of supplementation with magnesium, phosphate, or zinc in adult ICU patients.

The researchers registered the protocol, followed the Preferred Reporting Items for Systematic Review and Meta-Analysis statement, used the Cochrane risk of bias 2 tool, and the grading of recommendations, assessment, development and evaluation (GRADE) approach for assessing the certainty of the evidence.

How the Review Was Done

Primary outcomes were mortality and duration of mechanical ventilation.

What Was Measured

Low-serum levels of magnesium, phosphate, and zinc are observed in many intensive care unit (ICU) patients, but clinical equipoise exists regarding supplementation strategies.

Topics PubMed links to this paper include Magnesium, Zinc, Phosphates, Critical Care and Intensive Care Units.

Author keywords: critically ill and meta analysis.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (Acta anaesthesiologica Scandinavica), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.