Analgesic Effects of Preoperative Combination of Oral Pregabalin and Intravenous Magnesium Sulfate on Postoperative Pain in Patients Undergoing Posterolateral Spinal Fusion Surgery: A 4-arm, Randomized, Double-blind, Placebo-controlled Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Multimodal perioperative pain management including nonopioid analgesia is a major pillar of enhanced recovery after surgery programs.

Who Took Part

The study group was 104 patients.

Secondary outcomes included visual analog scale scores for leg pain at rest and with movement, and postoperative nausea and vomiting (PONV) in the first 48 hours after surgery.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

The study drugs were administered 1 hour preoperatively.

The primary outcome was the cumulative morphine consumption on postoperative day 1.

What Was Measured

The subject headings attached to it are Pregabalin, Magnesium Sulfate, Postoperative Nausea and Vomiting, Spinal Fusion, Saline Solution, Analgesics and Morphine.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 104 patients.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2024 (Journal of neurosurgical anesthesiology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.