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A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections.
Plain-language guide to PMID 36621376 (2023): double-blind randomized controlled trial of Copper (Supplement).
Key Facts
- PMID
- 36621376
- Journal
- European urology focus
- Year
- 2023
- Study type
- Randomized Controlled Trial
- Authors
- Salvatore S et al. (6 authors)
- DOI
- 10.1016/j.euf.2022.12.013
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Copper (Supplement).
Who Took Part
PubMed tags the participants as women only.
The participants were nonmenopausal women with an acute uncomplicated E. coli UTI.
Their results show that for nonmenopausal women with an uncomplicated Escherichia coli urinary tract infection, those treated with a dietary supplement (containing D-mannose, citric acid, prebiotic fibers, Astragalus, and dandelion) had a higher rate of clinical resolution or response than women who received a placebo.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.
Some participants received a placebo instead of Copper (Supplement), giving a reference point.
This was a single-center, randomized, double-blind, placebo-controlled trial conducted from April 2021 to October 2021 in Rajalakshmi Hospital and Research Centre (Bangalore, India).
UTI was diagnosed according to the presence of at least one urinary symptom and bacteriuria (>100 000 CFU/ml).
The control group received placebo with SOC.
What Was Measured
PubMed files the paper under topics including Mannose, Bacteriuria, Escherichia coli, India, Urinary Tract Infections, Escherichia coli Infections and Dietary Supplements.
The authors tagged it with the keywords D-Mannose.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement).
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2023 (European urology focus), a journal based in Netherlands.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.