Effects of Hypocaloric Low-Fat, Ketogenic, and Ketogenic and Ketone Supplement Diets on Aldosterone and Renin.

What Was Tested

This randomized controlled trial looks at Copper (Supplement).

Investigate the effects of KDs with varying sodium content vs LFD on RAAS in overweight and obese adults.

Linear mixed models with random intercepts were used to compare between group differences controlling for sex and body mass index.

Why It Was Studied

Ketogenic diets (KDs) and low-fat diets (LFD) result in similar weight loss, but have differential cardiometabolic effects on lipids and insulin.

Who Took Part

By PubMed's age tags, the people studied were adults, both men and women.

Twenty-eight participants were randomized 1:1 to a KD + ketone salt supplement (KD + KS) or a KD + placebo (KD + PL) arm with prepared hypocaloric meals.

Twelve participants were enrolled in a post hoc LFD arm.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Because people in this Copper (Supplement) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.

Serum renin, aldosterone, and anthropometric and metabolic biomarkers were assessed at 0, 2, 4, and 6 weeks.

What Was Measured

The subject headings attached to it are Ketones, Renin, Aldosterone, Diet, Fat-Restricted, Ketone Bodies, Diet, Ketogenic and Weight Loss.

Author keywords: adiposity and ketogenic diet.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Copper (Supplement).

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2023 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Copper (Supplement) compound page, all human trials.