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Effect of Adding l -Carnitine to Risperidone on Behavioral, Cognitive, Social, and Physical Symptoms in Children and Adolescents With Autism: A Randomized Double-Blinded Placebo-Controlled Clinical Trial
Plain-language guide to PMID 36735565 (2023): double-blind randomized controlled trial study of L-Carnitine in 50 children.
Key Facts
- PMID
- 36735565
- Journal
- Clinical neuropharmacology
- Year
- 2023
- Study type
- Randomized Controlled Trial
- Authors
- Shakibaei F et al. (2 authors)
- DOI
- 10.1097/WNF.0000000000000544
What This Study Did, in Plain Language
What Was Tested
Researchers studied L-Carnitine in this randomized controlled trial publication.
The present research aimed to evaluate the effect of adding l -carnitine to risperidone in treating children and adolescents with autism spectrum disorder (ASD).
Who Took Part
According to the abstract, 50 children were involved.
The age groups tagged for this paper are children and teenagers.
In this randomized controlled clinical trial study, 50 ASD children and adolescents were divided into 2 groups: those receiving l -carnitine and risperidone (n = 25) and those receiving placebo and risperidone (n = 25).
Treatment continued for 8 weeks, and participants were assessed at the beginning of the study, in the fourth and eighth weeks, by the Aberrant Behavior Checklist (ABC).
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The children were allocated by chance, so the L-Carnitine group and the comparison group should start out alike.
As a double-blind L-Carnitine study, the assignments were hidden from both participants and investigators until the end.
Some children received a placebo instead of L-Carnitine, giving a reference point.
The timeline in the abstract includes 8 weeks.
What Was Measured
PubMed files the paper under topics including Risperidone, Autistic Disorder, Antipsychotic Agents, Autism Spectrum Disorder, Carnitine, Lethargy and Cognition.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of L-Carnitine in 50 children over 8 weeks.
Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2023 (Clinical neuropharmacology), a journal based in United States.
More context: the L-Carnitine compound page, all human trials.
Our Notes on the Compound
L-Carnitine: An amino acid derivative that carries fatty acids into mitochondria for energy production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.