Effect of Laparoscopic Proximal Gastrectomy With Double-Tract Reconstruction vs Total Gastrectomy on Hemoglobin Level and Vitamin B12 Supplementation in Upper-Third Early Gastric Cancer: A Randomized Clinical Trial

What Was Tested

Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.

To evaluate the effect of laparoscopic PG with DTR (LPG-DTR) vs laparoscopic TG (LTG) on levels of hemoglobin and vitamin B12 supplementation required among patients with clinically early GC in the upper third of the stomach (upper-third early GC).

Why It Was Studied

Patients undergoing proximal gastrectomy (PG) with double-tract reconstruction (DTR) have been reported to have an incidence of reflux esophagitis that is as low as that observed after total gastrectomy (TG).

It is unclear whether PG has an advantage over TG for the treatment of patients with upper early gastric cancer (GC).

Who Took Part

According to the abstract, 138 patients were involved.

PubMed indexes the participants as middle-aged adults, both men and women.

A total of 138 patients with upper-third cT1N0M0 GC were enrolled between October 27, 2016, and September 9, 2018.

Patients were randomized to undergo either LPG-DTR or LTG.

How the Study Was Run

The design is described as randomized, open-label and multicenter.

The patients were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.

Being open-label, the Cyanocobalamin (Vitamin B12) study did not mask who received what.

More than one site took part, so the patients came from several places.

Follow-up ended on December 3, 2020.

What Was Measured

PubMed files the paper under topics including Dietary Supplements, Gastrectomy, Hemoglobins, Laparoscopy, Quality of Life, Stomach Neoplasms and Vitamin B 12.

What This Means in Plain Language

The paper is a randomized, open-label and multicenter study of Cyanocobalamin (Vitamin B12) in 138 patients.

The abstract goes on to report its results in about 14 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2023 (JAMA network open), a journal based in United States.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.