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Associations among serum VEGF and CGRP levels with the peripheral vascular blood flow of the skin of the hands in women with Fibromyalgia
Plain-language guide to PMID 36796914 (2023): observational study of CGRP (Calcitonin Gene-Related Peptide).
Key Facts
- PMID
- 36796914
- Journal
- Journal of thermal biology
- Year
- 2023
- Study type
- Observational Study
- Authors
- Casas-Barragán A et al. (6 authors)
- DOI
- 10.1016/j.jtherbio.2023.103469
What This Study Did, in Plain Language
What Was Tested
Researchers studied CGRP (Calcitonin Gene-Related Peptide) in this observational study publication.
The researchers aimed to analyze the associations among serum vascular endothelial growth factor (VEGF) and calcitonin gene-related peptide (CGRP) levels with the peripheral temperature of the skin of both hands and the core body temperature in patients with FM and healthy controls.
The researchers used an infrared thermography camera to assess the peripheral temperature of the skin of the dorsal thumb, index, middle, ring, and pinkie fingertips and dorsal centre as well as the palm thumb, index, middle, ring, and pinkie fingertips, palm centre and thenar and hypothenar eminences of both hands and an infrared thermographic scanner to record the tympanic membrane and axillary temperature.
Why It Was Studied
Fibromyalgia (FM) is a long-term condition of unknown physiopathology, whose hallmark symptoms are diffuse musculoskeletal chronic pain and fatigue.
Who Took Part
PubMed tags the participants as women only.
The researchers conducted a case-control observational study with fifty-three women diagnosed with FM and twenty-four healthy women.
How the Study Was Run
VEGF and CGRP levels were spectrophotometrically analyzed in serum by enzyme-linked immunosorbent assay.
What Was Measured
The subject headings attached to it are Vascular Endothelial Growth Factor A, Fibromyalgia, Calcitonin Gene-Related Peptide, Hand and Skin.
Author keywords: Core body temperature and Thermography.
What This Means in Plain Language
This is an observational study of CGRP (Calcitonin Gene-Related Peptide).
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2023 (Journal of thermal biology), a journal based in England.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, all human trials.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.