Vitamin D supplementation and hospitalization for infection in older adults: A post-hoc analysis of data from the Australian D-Health Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The objective of this study was to assess the effect of vitamin D supplementation on hospitalization for infection.

Who Took Part

By PubMed's age tags, the people studied were older adults, both men and women.

Hospitalization for infection, ascertained through linkage with hospital admitted patient data, is a tertiary outcome of the trial.

The researchers used negative binomial regression to estimate the effect of vitamin D supplementation on outcomes.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

The primary outcome for this post-hoc analysis was hospitalization for any infection.

Secondary outcomes were extended hospitalization for infection (length of stay >3 d and >6 d) and hospitalization for respiratory tract, skin, and gastrointestinal infections.

What Was Measured

Topics PubMed links to this paper include Australia, Vitamin D, Vitamins, Cholecalciferol, Dietary Supplements and Hospitalization.

Author keywords: gastrointestinal infection, infection, randomized controlled trial, respiratory tract infection, skin infection and vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (The American journal of clinical nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.