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The effect of growth hormone on the metabolome of follicular fluid in patients with diminished ovarian reserve.
Plain-language guide to PMID 36849898 (2023): observational study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Key Facts
- PMID
- 36849898
- Journal
- Reproductive biology and endocrinology : RB&E
- Year
- 2023
- Study type
- Observational Study
- Authors
- He F et al. (12 authors)
- DOI
- 10.1186/s12958-023-01073-x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as an observational study.
The Pearson correlation was performed to evaluate the relationship between the number of oocytes retrieved and the levels of differential metabolites.
Why It Was Studied
The composition of follicular fluid (FF) plays an essential role in oocyte development and mirrors the communication occurring between the oocyte and follicular microenvironment.
However, the effect of GH on the FF metabolome remains unclear.
Who Took Part
PubMed tags the participants as women only.
This prospective observational study recruited DOR patients undergoing in vitro fertilization (IVF) cycles with minimal stimulation protocol for COS.
Each patient receiving GH co-treatment was matched to a patient without GH co-treatment by propensity score matching.
How the Study Was Run
The FF was collected after isolating oocytes and assayed by gas chromatograph-mass spectrometry (GC-MS) metabolomics.
The KEGG database was used to map differential metabolites onto various metabolic pathways.
What Was Measured
PubMed files the paper under topics including Growth Hormone, Follicular Fluid, Ovarian Reserve, Human Growth Hormone, Metabolome, Ovarian Diseases and Succinates.
The authors tagged it with the keywords Diminished ovarian reserve, Gas chromatograph-mass spectrometry and Metabolomics.
What This Means in Plain Language
This is an observational study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2023 (Reproductive biology and endocrinology : RB&E), a journal based in England.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.