Low serum anti-Müllerian hormone is associated with semen quality in infertile men and not influenced by vitamin D supplementation.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Anti-Müllerian hormone (AMH) is released by testicular Sertoli cells and of great importance during fetal male sexual development, but less is known about the role of circulating AMH during adulthood.

Who Took Part

According to the abstract, 307 men were involved.

By PubMed's age tags, the people studied were adults, men only.

Explorative outcomes were associations between serum AMH and gonadal function in infertile men.

The primary endpoint was difference in semen quality and has previously been published.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The men were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the men nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some men received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

A single-center, double-blinded, randomized placebo-controlled clinical trial (NCT01304927) conducted in Copenhagen, Denmark.

Difference in serum AMH was a predefined secondary endpoint.

What Was Measured

Anti-Müllerian hormone (AMH) is released by testicular Sertoli cells and of great importance during fetal male sexual development, but less is known about the role of circulating AMH during adulthood.

The subject headings attached to it are Anti-Mullerian Hormone, Semen Analysis, Semen, Vitamin D, Cholecalciferol, Dietary Supplements and Follicle Stimulating Hormone.

Author keywords: AMH, Citamin D, Male infertility, Semen quality and Sertoli cell function.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 307 men.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2023 (BMC medicine), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.