Attenuating the Pressor Response to Laryngoscopy and Endotracheal Intubation in Controlled Hypertensives: The Effect of Combining Lidocaine and Magnesium Sulphate.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Laryngoscopy and intubation result in a pressor response which may be deleterious especially in hypertensives, resulting in potentially harmful effects.

Who Took Part

The side effects of study medication and changes in serum magnesium level prior to and after 30 minutes of administering study medication were documented.

How the Study Was Run

The design is described as randomized and double-blind.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

A prospective, randomized, double-blinded study.

The outcome was the change in the systolic blood pressure (SBP) from the baseline following administration of study medication and after laryngoscopy and endotracheal intubation.

What Was Measured

The subject headings attached to it are Magnesium Sulfate, Laryngoscopy, Magnesium, Intubation, Intratracheal and Lidocaine.

The authors tagged it with the keywords Haemodynamic response, Laryngoscopy and endotracheal intubation, Magnesium sulphate and Serum levels of MgSO4.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2023 (West African journal of medicine), a journal based in Nigeria.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.