Serum vitamin D le Serum vitamin D levels are associated with acute post e associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystect cholecystectomy: a str omy: a strobe compliant pr obe compliant prospectiv ospective obser e observational ational study.

Plain-language guide to PMID 36945925 (2023): double-blind observational study of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 36945925
Journal: Turkish journal of medical sciences
Year: 2023
Study type: Observational Study
Authors: Miniksar ÖH et al. (6 authors)
DOI: 10.55730/1300-0144.5570

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

In this prospective observational study, the researchers aimed to evaluate the relationship between serum levels of vitamin D and acute postoperative pain scores, as well as opioid analgesic consumption in patients undergoing laparoscopic cholecystectomy.

Who Took Part

Postoperative visual analog scale (VAS) pain scores, total tramadol consumption, number of requests on patient-controlled analgesia (PCA) were compared between the vitamin D deficient (≤20 ng/mL; n = 25) and vitamin D nondeficient (>20 ng/mL; n = 55) groups at five time points (T0: in the recovery room, T1: 1st hour in the ward, T2: 6th hour, T3: 12th hour, and T4: 24th hour).

How the Study Was Run

The design is described as double-blind.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

: The study was performed in the Medical Faculty Hospital, from April 2020 to April 2021.

What Was Measured

PubMed files the paper under topics including Analgesics, Opioid, Tramadol, Cholecystectomy, Laparoscopic, Postoperative Pain, Vitamin D and Vitamin D Deficiency.

Author keywords: analgesia and laparoscopy.

What This Means in Plain Language

The paper is a double-blind study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2023 (Turkish journal of medical sciences), a journal based in Turkey.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.