Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.

Plain-language guide to PMID 37060089 (2023): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 45 patients.

Key Facts

PMID: 37060089
Journal: Journal of orthopaedic surgery and research
Year: 2023
Study type: Randomized Controlled Trial
Authors: Zhao C et al. (5 authors)
DOI: 10.1186/s13018-023-03790-w

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Chinese Clinical Trial Registry, ChiCTR2200056549.

Registered on 7 February 2022, https://www.chictr.org.cn/showproj.aspx?proj=151489.

Who Took Part

The study group was 45 patients.

Ninety patients were randomly assigned to the magnesium sulfate and control groups, with 45 patients in each group.

In the magnesium sulfate group, patients were given a periarticular infusion of a cocktail of analgesics consisting of epinephrine, ropivacaine, magnesium sulfate, and dexamethasone.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

The control group received no magnesium sulfate.

The primary outcomes consisted of visual analogue scale (VAS) pain scores, postoperative morphine hydrochloride consumption for rescue analgesia, and time to first rescue analgesia.

Tertiary outcomes included the postoperative swelling ratio and complication rates.

What Was Measured

The subject headings attached to it are Arthroplasty, Replacement, Knee, Anesthetics, Local, Analgesia, Postoperative Pain, Morphine, Analgesics, Opioid and Analgesics.

The authors tagged it with the keywords Cocktail, Magnesium sulfate, Periarticular infiltration analgesia and Total knee arthroplasty.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 45 patients.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (Journal of orthopaedic surgery and research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.