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l-carnitine downregulate the muscle wasting effect of glucocorticoids in pemphigus patient: A randomized double-blind placebo-controlled study
Plain-language guide to PMID 37078370 (2023): double-blind randomized controlled trial study of L-Carnitine in 44 patients.
Key Facts
- PMID
- 37078370
- Journal
- Physiological reports
- Year
- 2023
- Study type
- Randomized Controlled Trial
- Authors
- Noormohammadi Z et al. (5 authors)
- DOI
- 10.14814/phy2.15657
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of L-Carnitine, published as a randomized controlled trial.
Considering the adverse effect of glucocorticoid therapy in pemphigus patients and altered muscle metabolism, this study aimed to investigate the effect of l-carnitine supplementation which can be useful in combating muscle-wasting impact of glucocorticoid therapy.
In this randomized double-blind placebo-controlled trial 44 pemphigus patients aged from 30 to 65 years, receiving glucocorticoid therapy were selected to evaluate the suitability of l-carnitine (LC) as an anti-wasting substance.
Why It Was Studied
Pemphigus Vulgaris (PV) is a blistering autoimmune disease caused by autoantibodies against desmoglein 1 and 3.
Treatment options are limited to corticosteroids and immunosuppressants.
Who Took Part
According to the abstract, 44 patients were involved.
The age groups tagged for this paper are adults, middle-aged adults and older adults.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got L-Carnitine and who got the comparison, which limits bias.
As a double-blind L-Carnitine study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with L-Carnitine could be set against what happens without it.
The timeline in the abstract includes 8 weeks.
What Was Measured
Topics PubMed links to this paper include Carnitine, Glucocorticoids, Pemphigus, Insulin-Like Growth Factor I, Myogenin, Myostatin and Muscular Atrophy.
The authors tagged it with the keywords IGF-1, creatine kinase and pemphigus vulgaris.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of L-Carnitine in 44 patients over 8 weeks.
The publication is from 2023 (Physiological reports), a journal based in United States.
More context: the L-Carnitine compound page, all human trials.
Our Notes on the Compound
L-Carnitine: An amino acid derivative that carries fatty acids into mitochondria for energy production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.