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Effect of vitamin D supplementation on glucose control in mid-late gestation: A randomized controlled trial.
Plain-language guide to PMID 37087832 (2023): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 1720 women.
Key Facts
- PMID
- 37087832
- Journal
- Clinical nutrition (Edinburgh, Scotland)
- Year
- 2023
- Study type
- Randomized Controlled Trial
- Authors
- Ma S et al. (11 authors)
- DOI
- 10.1016/j.clnu.2023.04.011
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
It is unclear whether vitamin D supplementation contributes to gestational glucose control and whether the specific effects vary in individuals with diverse genetic and metabolic contexts.
The study aimed to assess the effect of vitamin D supplementation during pregnancy on subsequent glucose levels and to identify factors modulating the response to vitamin D3 intake.
Who Took Part
According to the abstract, 1720 women were involved.
PubMed tags the participants as women only.
How the Study Was Run
The design is described as randomized, double-blind and multicenter.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
More than one site took part, so the women came from several places.
Outcomes were changes in serum 25-hydroxyvitamin D (25(OH)D) and fasting plasma glucose (FPG) levels from baseline, 32-36 weeks' gestation to delivery (37-41 weeks) quantified using a linear mixed model.
What Was Measured
PubMed files the paper under topics including Blood Glucose, Dietary Supplements, Vitamin D, Cholecalciferol and Vitamins.
The authors tagged it with the keywords 25-Hydroxyvitamin D, RCT and vitamin D supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and multicenter study of Vitamin D, K2, Magnesium and Zinc in 1720 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2023 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.