Hypotension duration and vasopressor requirements following intrathecal oxytocin for Total hip arthroplasty: Secondary analysis of a randomized controlled trial

What Was Tested

Researchers studied Oxytocin in this randomized controlled trial publication.

Who Took Part

According to the abstract, 90 patients were involved.

PubMed tags the participants as women only.

90 patients were included in the analysis (44 randomized to spinal oxytocin and 46 to placebo [saline]).

Data collected prospectively during the previously published study were supplemented with additional retrospectively collected data.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The patients were allocated by chance, so the Oxytocin group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received Oxytocin.

The comparison arm used a placebo, so changes seen with Oxytocin could be set against what happens without it.

The primary outcomes were comparisons of the duration of hypotension (minutes with mean arterial pressure < 65 mmHg) and cumulative vasopressor requirements during the initial 60 min following spinal placement.

Secondary outcomes included hypotension durations and vasopressor requirements at later time points, perioperative fluid administration, physical therapy metrics, time to first opioid administration, cumulative opioid consumption through 24 h, and verbal pain scores through 24 h.

What Was Measured

Topics PubMed links to this paper include Analgesics, Opioid, Oxytocin, Arthroplasty, Replacement, Hip, Injections, Spinal, Hypotension, Anesthesia, Spinal and Vasoconstrictor Agents.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Oxytocin in 90 patients.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (Journal of clinical anesthesia), a journal based in United States.

More context: the Oxytocin compound page, all human trials.