Effectiveness and safety of a cream product containing zinc oxide for alleviating mosquito bite symptoms.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a controlled clinical trial.

People frequently experience discomfort with immediate wheal, delayed papules, and pruritus from mosquito bites.

Who Took Part

The abstract describes 41 participants taking part.

An open-label, controlled study was performed on 41 healthy participants.

All subjects received Aedes aegypti mosquito bites on the forearm.

How the Study Was Run

The design is described as randomized and open-label.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Nothing was hidden in this open-label Vitamin D, K2, Magnesium and Zinc study: the participants and staff both knew the treatment.

Then test product was randomly applied to the bitten areas of the left or right arm.

The other arm was left untreated (control).

The onset of pruritus relief was noted.

The size of the bite reaction lesion was also measured at all time points.

Any local cutaneous adverse reactions observed during the study were documented.

What Was Measured

The subject headings attached to it are Aedes, Insect Bites and Stings, Pruritus, Skin and Zinc Oxide.

Author keywords: Mosquito bites.

What This Means in Plain Language

The paper is a randomized and open-label study of Vitamin D, K2, Magnesium and Zinc in 41 participants.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2023 (Cutaneous and ocular toxicology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.