Dual trigger improves the pregnancy rate in fresh in vitro fertilization (IVF) cycles compared with the human chorionic gonadotropin (hCG) trigger: a systematic review and meta-analysis of randomized trials.

What It Covers

Researchers studied hCG (human chorionic gonadotropin) in this meta-analysis publication.

Thus, a systematic review and meta-analysis of randomized trials were conducted to provide a comprehensive evaluation of the impact of the dual trigger on pregnancy outcomes in fresh or frozen embryo transfer cycles.

After dual trigger, delaying ET due to the concern of endometrial receptivity might not be needed.

Who the Included Studies Covered

PubMed tags the participants as women only.

The researchers searched the Medline and Embase databases for articles up to 2023 by using search terms: "dual trigger," "GnRHa," "hCG," "IVF." Eligible RCTs comparing the dual trigger with the hCG trigger were included.

How the Review Was Done

A systematic review and meta-analysis of randomised controlled trials (RCTs) were conducted.

The primary outcome was the live birth rate (LBR) per cycle.

The secondary outcomes were the number of oocytes retrieved, number of mature oocytes retrieved, implantation rate, biochemical pregnancy rate, CPR, miscarriage rate and ovarian hyperstimulation syndrome (OHSS) rate per started cycle the researchers compared the oocyte maturation and pregnancy outcomes in the dual trigger and hCG trigger groups.

What Was Measured

Thus, a systematic review and meta-analysis of randomized trials were conducted to provide a comprehensive evaluation of the impact of the dual trigger on pregnancy outcomes in fresh or frozen embryo transfer cycles.

The subject headings attached to it are Pregnancy Rate, Ovulation Induction, Gonadotropin-Releasing Hormone, Randomized Controlled Trials as Topic, Fertilization in Vitro and Chorionic Gonadotropin.

The authors tagged it with the keywords Dual trigger, GnRH agonist, Meta-analysis, Randomised trials, Systematic review and hCG.

What This Means in Plain Language

This is a meta-analysis of hCG (human chorionic gonadotropin).

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2023 (Journal of assisted reproduction and genetics), a journal based in Netherlands.

More context: the hCG (human chorionic gonadotropin) compound page, all human trials.